The Science

 

Volume deficits happen when dermal cells do not regenerate properly. These deficits can be seen as hollowness and skin sagging in certain areas. Weakness within the skin can occur with or without volume loss.

Volume loss, weakened skin and skin laxity is a product of intrinsic and extrinsic factors. Most notable examples are:

  • Sun exposure. UV damage (Extrinsic)
  • Repetitive facial expression (Intrinsic)
  • Too aggressive heat based procedures (extrinsic)
  • Lifestyle  factors which can include excessive exercise, stress, excess body fat, insufficient protein consumption (extrinsic)
  • menopause (intrinsic)

The Science behind Active Face Cream and Strong Body Cream:

Adipeau Active Face Cream synergistically works by promoting dermal fats cells to proliferate and mature with the Safflower oil, while the Black Ginger Root tones them. These healthy fat cells then, in turn tells the fibroblasts to make collagen and elastin, This regenerating  'root structure' of the  skin results in improved volume and strength.

There are many questions that can be asked. These questions may seem simple but many people, including many practitioners, would struggle to answer them correctly.

 Here are the most asked questions :

 

Yes, dermal white adipose cells are unique to the skin.

Cite

Driskell RR, Jahoda CA, Chuong CM, Watt FM, Horsley V. Defining dermal adipose tissue. Exp Dermatol. 2014 Sep;23(9):629-31. doi: 10.1111/exd.12450. PMID: 24841073; PMCID: PMC4282701.

 

No, new fat cells are constantly being made to replace ones that die.

Cite

Nguyen HP, Lin F, Yi D, Xie Y, Dinh J, Xue P, Sul HS. Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis. Dev Cell. 2021 May 17;56(10):1437-1451.e3. doi: 10.1016/j.devcel.2021.03.026. Epub 2021 Apr 19. PMID: 33878347; PMCID: PMC8137669.

 

Yes, dermal adipocytes have unique regenerative powers.

Cite

Chon SH, Pappas A. Differentiation and characterization of human facial subcutaneous adipocytes. Adipocyte. 2014 Nov 14;4(1):13-21. doi: 10.4161/21623945.2014.955402. PMID: 26167398; PMCID: PMC4496965.

 

In the lower dermis, in and around the vellus hair follicles.

Cite

Nicu C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. A guide to studying human dermal adipocytes in situ. Exp Dermatol. 2018 Jun;27(6):589-602. doi: 10.1111/exd.13549. PMID: 29603400.

 

There is no separation between dermal and subcutaneous adipocytes.

Cite

Nicu C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. A guide to studying human dermal adipocytes in situ. Exp Dermatol. 2018 Jun;27(6):589-602. doi: 10.1111/exd.13549. PMID: 29603400.

  

Immature fat cells or pre-adipocytes are more numerous than the mature fat cells.

Cite

Roberta Florido, Tamara Tchkonia, James L. Kirkland, Chapter 5 – Aging and Adipose Tissue, Editor(s): Edward J. Masoro, Steven N. Austad, In Handbooks of Aging, Handbook of the Biology of Aging (Seventh Edition), Academic Press, 2011, Pages 119-139, ISBN 9780123786388

 

Yes, small molecules less than 500 daltons are readily able to reach the skin’s fat cells via the hair follicle path.

Cite

Abd E, Benson HAE, Roberts MS, Grice JE. Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies. Skin Pharmacol Physiol. 2018;31(5):252-260. doi: 10.1159/000489857. Epub 2018 Jul 12. PMID: 30001555.

 

Yes, as adipocytes become large they stop promoting adipogenesis and start suppressing adipogenesis.

Cite

Stenkula KG, Erlanson-Albertsson C. Adipose cell size: importance in health and disease. Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R284-R295. doi: 10.1152/ajpregu.00257.2017. Epub 2018 Apr 11. PMID: 29641234.

 

Yes, large adipocytes instruct fibroblasts to reduce collagen, elastin and hyaluronic acid production by up to 80 percent.

Cite

Ezure T, Amano S. Negative regulation of dermal fibroblasts by enlarged adipocytes through release of free fatty acids. J Invest Dermatol. 2011 Oct;131(10):2004-9. doi: 10.1038/jid.2011.145. Epub 2011 Jun 23. PMID: 21697886

 

Yes, KPE reduces cell size by stimulating fat cells to release lipid.

Cite

Okabe Y, Shimada T, Horikawa T, Kinoshita K, Koyama K, Ichinose K, Aburada M, Takahashi K. Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora. Phytomedicine. 2014 May 15;21(6):800-6. doi: 10.1016/j.phymed.2014.01.014. Epub 2014 Mar 11. PMID: 24629599.

 

Yes, KPE promotes adipogenesis by increasing the number of PPARgamma transcripts.

Cite

Horikawa T, Shimada T, Okabe Y, Kinoshita K, Koyama K, Miyamoto K, Ichinose K, Takahashi K, Aburada M. Polymethoxyflavonoids from Kaempferia parviflora induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation. Biol Pharm Bull. 2012;35(5):686-92. doi: 10.1248/bpb.35.686. PMID: 22687402.

 

Yes, safflower seed oil is made of mostly long chain linoleic and oleic fatty acids.

Cite

Deliorman Orhan D, Pekacar S, Ulutaş OK, Özüpek B, Sümmeoğlu D, Berkkan A. Assessment of Commercially Safflower Oils (Carthami Oleum Raffinatum) in Terms of European Pharmacopoeia Criteria and Their Weight Control Potentials. Turk J Pharm Sci. 2022 Jun 27;19(3):273-279. doi: 10.4274/tjps.galenos.2021.84484. PMID: 35775241; PMCID: PMC9254086.

 

Yes, long chain fatty acids increase conversion of pre-adipocytes significantly.

Cite

Kokta TA, Strat AL, Papasani MR, Szasz JI, Dodson MV, Hill RA. Regulation of lipid accumulation in 3T3-L1 cells: insulin-independent and combined effects of fatty acids and insulin. Animal. 2008 Jan;2(1):92-9. doi: 10.1017/S1751731107000936. PMID: 22444967.

 

 

Yes, topically applied KPE penetrates readily into the dermal white adipose tissue.

Cite

Tuntiyasawasdikul S, Limpongsa E, Jaipakdee N, Sripanidkulchai B. Transdermal permeation of Kaempferia parviflora methoxyflavones from isopropyl myristate-based vehicles. AAPS PharmSciTech. 2014 Aug;15(4):947-55. doi: 10.1208/s12249-014-0122-y. Epub 2014 May 3. PMID: 24789664; PMCID: PMC4113614.

 

Yes, topically applied long-chain fatty acids penetrate readily into the dermal white adipose tissue.

Cite

Raufast V, Mavon A. Transfollicular delivery of linoleic acid in human scalp skin: permeation study and microautoradiographic analysis. Int J Cosmet Sci. 2006 Apr;28(2):117-23. doi: 10.1111/j.1467-2494.2006.00303.x. PMID: 18492146.

 

 


Frequently Asked Questions About Active Face Cream:


  1. Will I gain volume appearance where I don’t want it?

No, the skin knows where it needs new dermal fat cells and where it does not. Unlike a powerful drug, the cream can only nurture regeneration where it is meant to happen.

 

  1. Will the improvements in appearance go away when I stop using the cream?

Yes, and no. The improvements in strength appearance depend on your dermal fat cells maintaining a healthy size.  If you stop using the cream, the improvements in strength appearance may go away.  However, the improvements in volume appearance will last and may even continue to get better when you stop using the cream.  That’s because they are driven by the skin’s natural regeneration processes.

 

  1. How long do I need to use the cream to see improvements in strength appearance?

Usually, strength appearance starts to improve after three to four weeks and then stabilizes after 3 months.

 

  1. How long do I need to use the cream to see improvements in volume appearance?

Usually, volume appearance starts to improve after 6 weeks and continues to progress over many more months.  

 

  1. Can I use Adipeau with a retinol or retin-a?

Yes, we have customers who have successfully used the cream with a vitamin-A derivative. However, we don’t recommend the use of vitamin-A derivatives because they interfere with the skin’s natural regenerative processes.

 

  1. Can I use Adipeau with hyaluronic acid?

Yes, the original formulation of Adipeau even included hyaluronic acid.  However, we don’t recommend hyaluronic acid because it can make the skin barrier more porous and also interfere with the skin’s natural regenerative processes.

 

  1. Can I use Adipeau with niacinamide or vitamin C?

Yes, niacinamide and vitamin C support the skin in complementary ways.

 

  1. Can I use Adipeau with peptides?

Yes, peptide treatments will not penetrate deeply enough to interfere with use of Adipeau.  However, we recommend that Adipeau be applied before the topical peptide as these may block access to the hair follicle.

 

  1. Can I use Adipeau with red light therapy?

Yes, red light therapy complements the Adipeau by stimulating fibroblasts and also by reducing the size of the dermal fat cells. It’s important no to over use red light therapy.   The most established protocol is four weeks of red light treatment followed by three months off.

 

  1. Can I use Adipeau with at-home microcurrent?

We cannot recommend for or against at home microcurrent devices.

 

  1. Can I use Adipeau with at-home radiofrequency?

We recommend against using any type of at home radiofrequency.  Until we have better information from the manufacturers on the temperature achieved in the dermal fat compartment, it is our opinion that these devices are not safe to use.

 

  1. Can I use Adipeau on the hands and neck?

Yes, we have seen several cases where users achieved great results on the their hands and neck area with the cream.  We can’t scan these body parts objectively with our 3D scanner.

 

  1. Can I use Adipeau on the lips?

Yes, users have reported great results on the lips even though there are no hair follicles. This is likely because the barrier function of the lip skin epidermis is far more permissive than other facial skin.

 

Frequently Asked Questions About Strong Body Gel

Q - How often should I use Strong Body Gel?
A - Apply Strong Body Gel twice daily to the areas of concern (neck, arms, legs). For best results, apply consistently over four weeks.

Q - Is Strong Body Gel safe for all skin types?
A - Yes, Strong Body Gel is formulated for all skin types and is non-irritating. The formula is gentle enough for sensitive skin but effective enough to treat crepe-like areas.

Q - Can I use Strong Body Gel along with other body care products?
A - Absolutely. You can layer Strong Body Gel with your other body care routines like moisturizers or sunscreens. It’s lightweight and absorbs quickly.

Q - How long before I see results?
A - Most users notice visible improvements within 4 weeks of regular use. Results may vary depending on your skin type and condition.

Q - Which areas of my body can I use Strong Body Gel on?
A - Strong Body Gel is designed for weak or crepe-like skin on the neck, arms, and legs—especially in areas that experience frequent movement or sun exposure.

Q - Is Strong Body Gel tested on animals?
A - No, Adipeau is committed to cruelty-free practices. Our products are not tested on animals, and Active Face Cream is vegan-friendly.

 

 

Factors that slow down regeneration:

Age

 

Diet

Dynamic Facial movement

Excessive Exercise

Hormones

Procedures

Products

Sun exposure

Poor Circulation

Skin becomes weak when dermal  cells grow too large. This 'bloating" is causes by numerous factors which include age, products, High BMI and Poor Lymphatic.

When looking to address this problem, one needs to look at a holistic approach, which includes:

  • Protein rich diet which promotes regeneration
  • Regular exercise which is moderate aids small, dynamic fat cells
  • Removing excess lymph fluid results in less bloating of fat cells
  • Stimulating circulation with the correct treatments keeps growth factors flowing
  • Daily use of sunscreen
  • Daily use of ADIPEAU which nurtures and tones the dermal fat cells